The MC student chapter of the American Chemical Society is happy to announce that we are hosting Dr. Benjamin Miller on September 16th. Dr. Miller is visiting us from Rochester Medical Center, where he studies RNA-selective recognition by target molecules for the development of HIV treatment.
Please join us for his research seminar: "RNA-Targeted HIV Therapeutics"
"Sequence-selective RNA recognition represents an outstanding unsolved problem for the field of Bioorganic Chemistry. In contrast to DNA, there are no heuristics that can map an RNA sequence to a synthetic compound that binds on-ly that sequence.Dr. Benjamin Miller and his research team have developed Resin-Bound Dynamic Combinatorial Chemistry (RBDCC) as a method for addressing this challenge. RBDCC allows the rapid in situ syn-thesis and screening of large (>11,000-compound) libraries without the analytical challenges of “traditional” solution-phase dynamic combinatorial libraries. They have applied the RBDCC concept to several RNA targets, including one critical to the life cycle of HIV. This lecture will discuss the development of RBDCC, its use as an enabling tool for identifying sequence-selective RNA binders, and the further development of RBDCC-discovered compounds as lead molecules with target-relevant activity in vitro and in vivo. There will be a focus on the development of compounds able to alter -1 ribosomal frameshifting (recoding) in HIV, thereby inhibiting viral replication."